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Comparative study between Dexmedetomidine, Magnesium sulphate and Fentanyl as adjuvant to bupivacaine for postoperative epidural analgesia in abdominal surgeries

Comparative study between Dexmedetomidine, Magnesium sulphate and Fentanyl as adjuvant to bupivacaine for postoperative epidural analgesia in abdominal surgeries

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
PACTR
Registry ID
PACTR202509471921862
Enrollment
100
Registered
2025-09-29
Start date
2024-03-06
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

group C Bupivacaine and normal saline
Group D Dedmedetomidine and Bupivacaine
Group F Bupivacaine and Fentanyl
Group M Bupivacaine and Mg sulfate

Sponsors

Al Azhar University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: American society of Anesthiology Physical Status Classification System (ASA) physical status I and II Co-operative patients and willing for the procedure

Exclusion criteria

Exclusion criteria: Pregnant or lactating females. Patients with body mass index BMI more than 35 kg per m2. Patients with ASA physical status III and IV. Patients on therapy with adrenergic receptor antagonist, calcium channel blocker and or ACE inhibitors. Concomitant cardiovascular disease. Documented coagulation abnormality or abnormal bleeding history. Evidence of infection or anatomic abnormality at the proposed catheter insertion site. Difficult epidural placement, inadvertent epidural puncture (wet tap). History of hypersensitivity to drugs used in the study. Emergency operation. Failed block or need for induction of general anesthesia. Patients who have received opioids 24 hours before catheter insertion. Patient refusal or unable to give informed voluntary consent.

Design outcomes

Primary

MeasureTime frame
duration of analgesia

Secondary

MeasureTime frame
side effects

Countries

Egypt

Contacts

Public ContactMahmoud Ahmed

lecture of anesthesia and pain management

aliaashoip153@gmail.com00201008223320

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026