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Comparative split face study for the efficacy and safety of micro-needling alone versus micro-needling combined with botulinum toxin-A or autologous stem cells or irradiated amniotic collagen matrix in the treatment of atrophic acne scars

Comparative split face study for the efficacy and safety of micro-needling alone versus micro-needling combined with botulinum toxin-A or autologous stem cells or irradiated amniotic collagen matrix in the treatment of atrophic acne scars

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
PACTR
Registry ID
PACTR202508850407266
Enrollment
60
Registered
2025-08-04
Start date
2024-01-01
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin and Connective Tissue Diseases

Interventions

botulinum toxin a
autologous stem cells
irradiated amniotic collagen

Sponsors

tanta universty
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: .1-Patients aged 18-50 years presented with atrophic post-acne scars. 2-Patients who will accept to be included in the study, and will sign a written consent. 3-Patients agreed to participate after full explanation of the procedure

Exclusion criteria

Exclusion criteria: 1-Patients who have any hypersensitivity reactions to BTX-A or autologous stem cells or amniotic collagen matrix or any material used in the study. 2-Pregnant and lactating women. .3-Patients with active inflammatory acne or active infection in the treatment area. 4-Patients with premalignant or malignant lesions in the treatment area. 5-Patients with photosensitive dermatoses. 6-Patients with a history of chronic diseases (liver or kidney diseases). 7-Patients with coagulation defects and blood diseases

Design outcomes

Primary

MeasureTime frame
evaluation the efficacy and safety of micro-needling alone versus micro-needling combined with BTX-A, or combined with Autologous Cell Micro-graft, or combined with irradiated amniotic collagen matrix in the treatment of Atrophic Post-Acne Scars.—

Secondary

MeasureTime frame
evaluation effect in degree of patient satisfaction—

Countries

Egypt

Contacts

Public Contactmarwa magdy

doctor

marwa.agiza89@gmail.com+20155376762

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026