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The efficacy of misoprostol plus tranexamic acid and peri cervical tourniquet versus misoprostol plus peri cervical tourniquet in reducing blood loss during abdominal myomectomy at a tertiary health facility in Abuja, Nigeria: A randomized control trial.

The efficacy of misoprostol plus tranexamic acid and peri cervical tourniquet versus misoprostol plus peri cervical tourniquet in reducing blood loss during abdominal myomectomy at a tertiary health facility in Abuja, Nigeria: A randomized control trial.

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
PACTR
Registry ID
PACTR202508845388900
Enrollment
152
Registered
2025-08-26
Start date
2025-09-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uterine myoma

Interventions

Misoprostol and water for injection
misoprostol and tranexamic acid

Sponsors

Fatima Inusa Anga
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. All women for open myomectomy who have consented for this study. 2. Preoperative haemoglobin level of = 10g/dl

Exclusion criteria

Exclusion criteria: 1. History of underlying comorbidities such as diabetes mellitus, cardiac disease, bleeding disorders 2. Women that have allergy to misoprostol or tranexamic acid. 3. Other uterine conditions such as endometriosis, adenomyosis, or malignancy. 4. Women undergoing any other form of treatment for symptomatic uterine myoma other than abdominal myomectomy.

Design outcomes

Primary

MeasureTime frame
The volume of intra-operative blood loss.—

Secondary

MeasureTime frame
1. Mean change in the HB level (differences between the preoperative HB and postoperative HB estimated after 48 hours. 2. Post operative transfusion done. 3. Side effects of tranexamic acid and misoprostol.—

Countries

Nigeria

Contacts

Public ContactSafiya Faruk

Consultant Obstetrics and Gynecology

safiyafaruk@yahoo.com+2347067503320

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026