The role of trans cranial doppler &value of S100B protein in predicting neuronal damage in patients with acute Central nervous system infection

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202508836169766

Enrollment

Registered

2025-08-28

Start date

2023-08-10

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Central nervous system infection

Interventions

trans cranial doppler

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed as meningo encephalitis with fever , altered mental status & meningeal signs. Patients aged from 20 _ 60 years

Exclusion criteria

Exclusion criteria: Patients with prior history of other Central nervous system disease Patients with metabolic encephalopathy Patients with traumatic brain injury Other sepsis cause

Design outcomes

Primary

Measure	Time frame
Trans cranial doppler measures cerebral blood flow velocity at different times. CSF S100b protein value correlation with severity of infection	—

Secondary

Measure	Time frame
Length of stay. Mechanical ventilation days. Clinical disability & mortality	—

Countries

Egypt

Contacts

Public ContactMohammed ;Wafiya Mahmoud Torayah;Ramadan Mahdy

Lecturer;Lecturer

Mohammad.torayah@med.menofia.edu.eg;Wafia.mahdi@med.menofia.edu.eg01003727073;01094245826

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026