Skip to content

Effectiveness of Low Dose Magnesium Sulphate Versus Pritchard Regimen in Management of Severe Preeclampsia and Eclampsia in Ahmadu Bello University Teaching Hospital Zaria- A Randomised Controlled Trial

Effectiveness of Low Dose Magnesium Sulphate Versus Pritchard Regimen in Management of Severe Preeclampsia and Eclampsia in Ahmadu Bello University Teaching Hospital Zaria- A Randomised Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202508772932490
Enrollment
152
Registered
2025-08-22
Start date
2025-09-30
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preeclampsia and eclampsia

Interventions

Sponsors

Self
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: All women diagnosed with preeclampsia admitted into the labour ward of ABUTH Zaria who consent to participate in the study. All women diagnosed with eclampsia admitted into the labour ward of ABUTH Zaria who consent to participate in the study.

Exclusion criteria

Exclusion criteria: Pregnancies less than 28 weeks' gestation based on last menstrual period or early USS, admitted into the labour ward. Those who had loading dose of MgSO4 prior to presentation. Those treated with other anticonvulsants prior to presentation Multiple gestation Intrauterine fetal death at presentation. Known allergy to Magnesium sulphate Moribund patients with preeclampsia and eclampsia

Design outcomes

Primary

MeasureTime frame
The occurrence and recurrence of seizures in patients with preeclampsia and eclampsia following administration of the low dose and Pritchard MgSO4 regimen and Pritchard regimen.

Secondary

MeasureTime frame
Maternal outcome such as signs of MgSO4 toxicity, mode of delivery, need for rescue dose of MgSO4, ICU admission, maternal complications like visual loss, pulmonary oedema, DIC, HELLP syndrome and acute kidney injury as well as maternal mortality. Neonatal outcome such as APGAR in 1 and 5 minutes, birth weight, need for rescue dose, NICU admission and perinatal mortality

Countries

Nigeria

Contacts

Public ContactIjeoma Etukudo

PhD candidate Ahmadu Bello University Zaria

ijeomablessing2016@gmail.com+23478038520441

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026