Oral Health
Conditions
Interventions
Tranexamic acid
Normal saline
Sponsors
Taofeek Akinniyi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • ASA I and II (American Society of Anaesthesiology I) patients i.e. healthy patient with no systemic diseases. • Patients between the ages of 18-40 years • Patients with moderately impacted mandibular third molar (Class I or II, Position A or B) or Pederson’s difficulty index of 5-6 • Patient with no sign of pericoronitis, abscess, or systemic infection • Patient that is willing to participate and provide informed consent
Exclusion criteria
Exclusion criteria: • Presence of bleeding disorders that can lead to uncontrollable post-operative bleeding • Patients on anticoagulant/antiplatelet therapy. These patients are prone to prolong bleeding during and after surgery. • Allergy to tranexamic acid or any study-related medications • Patient on anti-inflammatory or analgesic medications within 48 hours prior to surgery • Patient with previous history of radiation therapy to the head and neck region • Patients with peptic ulcer disease (PUD). The study participants were placed on ibuprofen tablets, 400mg 8 hourly for 3 days after the mandibular third molar surgery. Ibuprofen, a non-steroidal anti-inflammatory drug is contraindicated in peptic ulcer disease patients. • Immunocompromised patients or those with uncontrolled systemic illness • Pregnant or nursing mothers ibuprofen is not totally safe in pregnancy. Ibuprofen is a non-steroidal anti-inflammatory drug and is classified as a US FDA pregnancy category C drug which its use is contraindicated in pregnancy. Ibuprofen is also excreted in breast milk and thus contraindicated in nursing mothers. • Patients with a known allergy to penicillin because subjects will be placed on amoxicillin post-operatively • Patients with a known history of allergy to lignocaine. This is because 2% lignocaine will be used as a local anaesthetic agent. • Patients with acute pericoronitis. This is because surgical extraction of impacted mandibular third molar is contraindicated in areas with acute infection • Patients with pre-operative pain not due to pericoronitis. This is to ensure that post-operative pain measurement is secondary to the procedure. • Patients who smoke. Smoking is known to have an inhibitory effect on wound healing following teeth extraction. • Non consenting patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain, postoperative swelling, postoperative trismus | — |
Secondary
| Measure | Time frame |
|---|---|
| Oral health related quality of life | — |
Countries
Nigeria
Contacts
Public ContactTaofeek Akinniyi
Hospital Consultant
Outcome results
None listed