Circulatory System HIV/AIDS
Conditions
Interventions
statins and anti oxidants supplementation groups
control
Statin only group
Antioxidant only group
Sponsors
Africa Center of Excellence for Population Health and Policy
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria Participants must meet all of the following to be eligible: 1. Adults aged 18 to 65 years. 2. Confirmed diagnosis of HIV infection using standard national testing algorithms. 3. On stable antiretroviral therapy (ART) for at least 6 months before enrollment. 4. Viral load < 1,000 copies/mL within the last 6 months (suppressed or controlled HIV). 5. Willing and able to provide written informed consent. 6. Able to comply with the study protocol, including clinic visits, blood sample collections, and ultrasound procedures. 7. Not currently on statin or antioxidant supplements.
Exclusion criteria
Exclusion criteria: Exclusion Criteria Participants will be excluded if they meet any of the following: 1. History of cardiovascular events, including myocardial infarction, stroke, or revascularization procedures. 2. Known diabetes mellitus or uncontrolled hypertension (BP =160/100 mmHg). 3. Current or recent (within 3 months) use of statins, antioxidants, or any lipid-lowering or anti-inflammatory therapy. 4. Pregnant or breastfeeding women. 5. Known renal impairment (eGFR 3× upper limit of normal). 6. History of statin intolerance, myopathy, or rhabdomyolysis. 7. Current active opportunistic infections or malignancies requiring treatment. 8. Enrolled in another clinical trial within the last 3 months. 9. Any condition deemed by the investigator to compromise participant safety or the integrity of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endothelial function will be assessed using brachial artery flow-mediated dilation (FMD), a well-established ultrasonographic measure of vascular reactivity. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters: Systolic and diastolic blood pressure, pulse rate. Lipid profile: Serum levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, total cholesterol, and triglycerides, measured via enzymatic assays. Inflammatory markers: Serum C-reactive protein (CRP). | — |
Countries
Nigeria
Contacts
Public ContactUmar ;Aisha Sharif Abdussalam;M Nalado
Senior Lecturer;PROFESSOR
Outcome results
None listed