Comparative study between the use of topical glyceryl trinitrate vs topical calcium channel blocker (diltiazem) in the treatment of chronic anal fissure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202507821064255

Enrollment

Registered

2025-07-23

Start date

2024-03-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery

Interventions

GTN group

diltiazem group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: chronic anal fissure

Exclusion criteria

Exclusion criteria: specific local pathological conditions (like Crohn’s disease, anal cancers, or tuberculosis) associated complaints (like abscesses or fistulas) history of previous perineal surgery presumed or confirmed pregnancy or lactation allergy to diltiazem or GTN chronic headache.

Design outcomes

Primary

Measure	Time frame
The treatment rates in both groups	—

Secondary

Measure	Time frame
side effects in both groups	—

Countries

Egypt

Contacts

Public ContactAbd Al Kareem Elias Abd Al Kareem

Assistant Professor of surgery Faculty of Medicine Al Azhar University Assiut

kareemgerem1235.el@azhar.edu.eg+201093959901

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026