Exploring potential pathogenesis mechanisms of onchocerciasis-associated epilepsy through cerebrospinal fluid analysis of children with complex febrile seizures

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202507670131109

Enrollment

100

Registered

2025-07-14

Start date

2025-09-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

onchocerciasis Nervous System Diseases Paediatrics

Interventions

Onchocerca volvulus biomarkers

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Ivermectin-naïve children aged between 2-5 years in onchocerciasis foci with suspected complex febrile seizures

Exclusion criteria

Exclusion criteria: previously treated with ivermectin

Design outcomes

Primary

Measure	Time frame
It is an observational study of children with febrile seizures to investigate whether certain of these febrile seizures could be caused by an Onchocerca volvulus infection and whether this could lead to onchocerciasis-associated epilepsy. Onchocerca volvulus biomarkers in cerebrospinal fluid.	—

Secondary

Measure	Time frame
Development of epilepsy	—

Countries

Democratic Republic of the Congo

Contacts

Public ContactRobert Colebunders

Professor

robert.colebunders@uantwerpen.be32486920149

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026