Adjunctive intravenous tranexamic acid versus vaginal misoprostol with catheter tourniquet for blood loss reduction during open abdominal myomectomy in Maiduguri: A randomized comparative study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202506900439697

Enrollment

Registered

2025-06-26

Start date

2025-07-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery

Interventions

Tranexamic acid group Group 1

Misoprostol group

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1) Patients with diagnosis of uterine fibroids requiring open abdominal myomectomy 2) Women without pre-operative anaemia (ie Haemogloblin concentration greater than or equal 10g/dl

Exclusion criteria

Exclusion criteria: 1) Known allergy to prostaglandins including misoprostol 2) Known allergy to tranexamic acid 3) Previous myomectomy or caesarean section 4) Chronic medical disorders like hypertension, diabetes 5) Known bleeding or clotting disorder

Design outcomes

Primary

Measure	Time frame
The mean intra-operative blood loss in both groups	—

Secondary

Measure	Time frame
1. Need for intra-operatively blood transfusion in both groups 2. The mean post-operative haematocrit value in both groups 3. The need for post-operative blood transfusion in both groups 4. The mean differences in the pre-operative and post-operative haematocrit in both groups 5. Occurence of side effects in both groups 6. Need for hysterectomy in both groups	—

Countries

Nigeria

Contacts

Public ContactGideon Malgwi

Senior Registrar

malgwigidds89@gmail.com+2347033278713

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026