Urological and Genital Diseases
Conditions
Interventions
Tadalafil capsule
Combination of tadalafil and tamsulosin
Sponsors
Tanta University Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Male patients above 50 years old and less than 80 years old who presented by LUTs due to BPH: - IPPS more than 7 - PVR less than 150 cc - Ability to provide informed consent and comply with study requirements
Exclusion criteria
Exclusion criteria: - Suspicious Cancer prostate. - Complicated BPH (refractory urine retention, recurrent UTI, recurrent Urinary bladder stone, gross hematuria secondary to BPH). - Insufficient renal function (s. creatinine >2 mg/dl) - Spinal cord injury - Active urinary tract infection - Cardiovascular diseases (unstable angina, recent myocardial infarction, poorly controlled blood pressure) - Hypotension - Recent treatment with nitrate - Previous prostate surgery (e.g. TURP, prostatectomy) - Urinary bladder cancer - Known hypersensitivity to study medication - Patient refused to be rolled in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in International Prostate Symptom Score (IPSS) from baseline to 12 weeks following start of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| - Quality of life assessment (BPH-QOL) - Improvement in peak urinary flow rate (Q-max) - Assessment of side effects and adverse events - Effect on erectile function | — |
Countries
Egypt
Contacts
Public ContactAyman Hassan
Professor of Urology at Tanta University Hospital
Outcome results
None listed