Effectiveness of Locally Delivered Clindamycin to Root Planing

Effectiveness of Local Delivery of Clindamycin Gel as an Adjunct to Scaling and Root Debridement: A Randomized Split-Mouth Design

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202506804878602

Enrollment

Registered

2025-06-05

Start date

2025-06-23

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Health

Interventions

Effectiveness of Local Delivery of Clindamycin Gel as an Adjunct to Scaling and Root Debridement

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with a bilaterally matched pair of permanent molars/premolars with moderate to severe periodontitis (4mm – 7mm PPD) without periodontal therapy in the last 3 months. 2. Systemically healthy patients with moderate to severe periodontitis 3. Patients with a minimum of 20 teeth, with periodontal pocket depth of between 4mm to 7 mm on both sides of the mouth, excluding third molars. Moderate periodontitis: Interdental CAL 3-4mm, PD = 5mm. Severe Periodontitis: Interdental CAL =5mm and PD 6-7mm. 4. Patients aged 18 years and above. 5. Motivated patient ready to keep to good oral hygiene

Exclusion criteria

Exclusion criteria: 1. Patients with systemic diseases (e.g., diabetes mellitus, hypertension, rheumatoid arthritis, respiratory disease(asthma), and osteoporosis) 2. Patients on cancer therapy 3. Pregnant and lactating women 4. History of smoking and smoking of any form of tobacco 5. Patients who have had periodontal treatment within the last 3 months 6. Patients who have a history of allergy to clindamycin and its analogues (e.g., Azithromycin, Clarithromycin, pirlimycin, U-57930E, and 7-halo-7-deoxylincomycin) 7. Patients with conditions requiring antibiotic prophylaxis before dental appointments and procedures 8. Patients with active infections such as HIV, hepatitis, or tuberculosis 9. Teeth with pockets in close proximity to a dental appliance 10. Teeth with pockets at the gingival border of an implant 11. Patients with vertical root fracture 12. Patients on medications that may have effects on the periodontium such as NSAIDs 13. Mentally ill patient

Design outcomes

Primary

Measure	Time frame
Primary outcomes to be measured in millimeters at each study visit (baseline, a month, and three months), are: 1.Probing Pocket depth (PPD), which is defined as the distance in mm from the crest of the gingival margin to the base of the sulcus/pockets on six sites of the tooth, except for the third molars. 2.Clinical attachment level (CAL), which is the distance measured from the cementoenamel junction (CEJ) to the base of the periodontal pocket.	—

Measure

Time frame

Primary outcomes to be measured in millimeters at each study visit (baseline, a month, and three months), are: 1.Probing Pocket depth (PPD), which is defined as the distance in mm from the crest of the gingival margin to the base of the sulcus/pockets on six sites of the tooth, except for the third molars. 2.Clinical attachment level (CAL), which is the distance measured from the cementoenamel junction (CEJ) to the base of the periodontal pocket.

—

Secondary

Measure	Time frame
Secondary outcomes to be assessed at each study visit (baseline, a month, and three months), are: 1. Plaque Index (Silness and Löe 1964) 2. Gingival Index (Löe and Silness 1963	—

Countries

Nigeria

Contacts

Public ContactModupe Arowojolu

Consultant Periodontologist

dupearo@yahoo.com+234803328353

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026