Hyoscine butyl bromide versus misoprostol for cervical priming before diagnostic hysteroscopy in premenopausal infertile women in Enugu southeastern Nigeria: A double-blinded randomised controlled trial

Hyoscine bromide versus misoprostol for cervical priming before diagnostic hysteroscopy in premenopausal infertile women in Enugu southeastern Nigeria: A double-blinded randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202506541899773

Enrollment

110

Registered

2025-06-02

Start date

2025-06-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility-female

Interventions

hyoscine

misoprostol

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: - Consenting women in reproductive age group (20 – 45 years)

Exclusion criteria

Exclusion criteria: - Women with known allergy to prostaglandins - Contra indications to use of prostaglandins (asthma, renal failure, glaucoma) - Uncontrolled diabetes mellitus - Pregnancy - Previous cervical surgeries - Women with cervicitis or active pelvic inflammatory disease

Design outcomes

Primary

Measure	Time frame
Proportion of participants that would require mechanical cervical dilatation during diagnostic hysteroscopy using Vaginal hyoscine bromide and misoprostol	—

Secondary

Measure	Time frame
This will include mean time for mechanical cervical dilatation, mean cervical dilatation width, mean time for mechanical cervical dilatation, mean time duration of diagnostic hysteroscopy, incidence of occurrence of complications (cervical laceration, uterine perforation, uterine bleeding, vaginal bleeding), incidence of occurrence of side effect of the medications (diarrhea, vomiting, lower abdominal cramps, fever, tachycardia, flushing, dry mouth, blurred vision) in the two groups	—

Measure

Time frame

This will include mean time for mechanical cervical dilatation, mean cervical dilatation width, mean time for mechanical cervical dilatation, mean time duration of diagnostic hysteroscopy, incidence of occurrence of complications (cervical laceration, uterine perforation, uterine bleeding, vaginal bleeding), incidence of occurrence of side effect of the medications (diarrhea, vomiting, lower abdominal cramps, fever, tachycardia, flushing, dry mouth, blurred vision) in the two groups

—

Countries

Nigeria

Contacts

Public ContactEMEKA ILOGHALU

CONSULTANT GYNAECOLOGIST

emefil@yahoo.com08033797981

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026