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EFFECT OF INJECTABLE PLATELET-RICH FIBRIN ON CLINICAL AND INFLAMMATORY PARAMETERS AS ADJUNCT TO SCALING AND ROOT PLANING AMONG PATIENTS WITH PERIODONTITIS – A RANDOMIZED CONTROLLED TRIAL

Effect of injectable platelet-rich fibrin on clinical and inflammatory parameters as adjunct to scaling and root planing among patients with periodontitis – a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
PACTR
Registry ID
PACTR202505856974120
Enrollment
50
Registered
2025-05-20
Start date
2025-08-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Health

Interventions

Injectable platelet rich fibrin.
Chlorhexidine

Sponsors

Olarinmoye Olaoluwa
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1. Adult patients 18 years of age and above. 2. Participant diagnosed with Stages III to IV periodontitis according to the staging and grading of periodontitis. 3. Subjects must have willingly and voluntarily signed the informed consent form. 4. Subjects with good systemic health (ASA I/ II)

Exclusion criteria

Exclusion criteria: 1. Patient with any systemic disease/condition such as (diabetes mellitus, Pregnancy, leukemia) that affects or modifies the periodontium. 2. Patients on medications such as calcium channel blockers, immunosuppressants, steroids that interfere with gingival tissue and healing of the periodontium in the preceding 6 months. 3. Patient with clotting or hematological disorders such as thrombocytopenia which may affect the quality of platelet to be extracted. 4. Current smokers; will be excluded through history taking. Following smoking cessation, participate that have not smoke tobacco for a minimum of 12 months will be included in the study. 5. Patients on antibiotic therapy in the preceding 3 months.

Design outcomes

Primary

MeasureTime frame
Number of sites with probing pocket depth (PPD) of 5mm and above, Number of sites with Clinical Attachment Loss (CAL) of 2mm and above.

Secondary

MeasureTime frame
Percentage periodontitis sites with gingival bleeding, Number of teeth with mobility, Grade of tooth mobility, tooth loss, high sensitivity C Reactive Protein level.

Countries

Nigeria

Contacts

Public ContactUmeizudike Kehinde

Prinicipal supervisor

kumeiz09@gmail.com+2348055451018

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026