Does combined doxycycline and autologous blood patch more effective autologous blood patch alone for management of persistent air leak in patients with secondary spontaneous pneumothorax : A randomized control trial

Efficacy of combined doxycycline and autologous blood patch versus autologous blood patch alone for management of persistent air leak in patients with secondary spontaneous pneumothorax : A randomized control trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

PACTR

Registry ID

PACTR202505753650802

Enrollment

Registered

2025-05-06

Start date

2025-01-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory

Interventions

Autologous blood patch pleurodesis.

autologous blood patch pleurodesis with doxycycline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1- Adult patients of both sexes Age =18 2- Patients with secondary spontaneous pneumothorax and persistent air leak =7 days (grade 1-2). Air leak was graded based on Cerfolio classification of air leak

Exclusion criteria

Exclusion criteria: 1- Previous history of ipsilateral pleurodesis. 2- Traumatic or primary spontaneous pneumothorax. 3- Patients with underlying haematological disorders- coagulopathies. 4- Known case of allergy to doxycycline 5- Patients with active pulmonary infection

Design outcomes

Primary

Measure	Time frame
A-Primary outcomes Rate of complete cessation of air leak between both groups. Leak until the seventh day of procedure was considered as success	—

Secondary

Measure	Time frame
B- Secondary outcomes • Length of hospital stay • Post-procedure complications including fever, tachycardia, emphysema, dyspnea and pain scoring using the numeric pain rating scale	—

Countries

Egypt, Saudi Arabia

Contacts

Public ContactAYMAN YOUSEF

consultant thoracic surgery

abusitte@yahoo.com00966500667132

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026