Anaesthesia
Conditions
Interventions
Rocuronium bromide with magnesium sulfate
Succinylcholine with Saline
Sponsors
Ain shams university faculty of medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Age between 18 and 60 Body mass index less than 30 kg/m2 Mallampati score I to II, and Cormack and Lehane grade I to II Physical status: American Society of Anesthesiologists (ASA) physical status I and II Elective operation, lasting longer than one hour, under general anesthesia
Exclusion criteria
Exclusion criteria: Known allergies to drugs used (rocuronium, succinylcholine and/or magnesium sulfate) ASA III or IV Suspected difficult ventilation, intubation, Mallampati score III or IV, or Cormack and Lehane grade III or IV Neuromuscular disease History of malignant hyperthermia Preoperative medications known to influence neuromuscular function (eg, certain antibiotics (amino glycosides), anticonvulsant (phenytoin) Electrolyte abnormalities (e.g., hypermagnesemia or hyperkalemia) Hepatic dysfunction (i.e., bilirubin >1.5 × upper limit of normal [ULN], alanine aminotransferase (ALT)>2.5 × ULN, aspartate aminotransferase (AST)>2.5 × ULN). Renal insufficiency (i.e., creatinine >1.5 × ULN) Atrioventricular heart block Patients on magnesium treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It will be to determine the number and percentage of patients with excellent intubating conditions. The assessment will be based on: 1. The ease of laryngoscopy: -Easy (jaw relaxed, no resistance to blade insertion). -Fair (jaw not fully relaxed, slight resistance to blade insertion). -Difficult (poor jaw relaxation, active resistance of the patient to laryngoscopy). 2. The position of the vocal cords: Abducted/Intermediate or moving/Closed. 3. The patient's response to the insertion of the endotracheal tube and cuff inflation (diaphragmatic movement/coughing): None Slight: One to 2 weak contractions and/or movement for <5 sec Vigorous or sustained: More than 2 contractions and/or movement for longer than 5 sec. The intubation conditions were classified as: Excellent: All qualities are excellent; easy laryngoscopy, abducted vocal cords, no response to the insertion of the endotracheal tube and cuff inflation. Good: All qualities are either excellent or good; fair laryngoscopy, intermediate or moving vocal cords, slight response to the insertion of the endotracheal tube and cuff inflation. Poor: The presence of a single quality listed under “poor” as difficult laryngoscopy, closed vocal cords, vigorous or sustained response to the insertion of the endotracheal tube and cuff inflation, based on a modified scale following the guidelines of Good Clinical Research Practice in Neuromuscular Research | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate, as well as systolic and diastolic blood pressure: Measured immediately before intubation and at 1 and 5 minutes following intubation. Safety was assessed by monitoring of: 1-Spontaneously reported symptoms and complaints during the infusion of magnesium pretreatment (such as nausea, retching, skin rash, and injection site pain) 2-Signs of histamine release (including bronchospasm, erythema, edema, and hypotension) after the administration of the neuromuscular blocking agents. 3-Signs of intraoperative awareness, muscle pain, and any minor or major adverse events. | — |
Countries
Egypt
Contacts
Public ContactMohamed Abdelwahab
Resident of anesthesia and intensive care medicine
Outcome results
None listed