Integrated Use of NGAL, Cystatin C, and Renal Resistive Index for Early Diagnosis and Subtyping of Acute Kidney Injury in Decompensated Cirrhosis: A Prospective Study from an HCV-Endemic Region

" Biomarkers of Acute Kidney Injury in Decompensated Cirrhosis in Zagazig University Hospitals "

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202505555006910

Enrollment

120

Registered

2025-05-14

Start date

2023-12-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urological and Genital Diseases

Interventions

NGAL Cystatin C RRI for AKI Diagnosis

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Adults (=18 years) with decompensated cirrhosis (confirmed by histology or clinical/imaging/biochemical evidence). - Presence of ascites (detected on abdominal ultrasonography). - Hospitalized =24 hours (to capture early AKI biomarkers). - Willingness to provide informed consent (or consent from legally authorized representatives for encephalopathy patients).

Exclusion criteria

Exclusion criteria: - ESRD (eGFR <15 mL/min/1.73 m² or dialysis). - Hepatocellular carcinoma (multifocal). - Recent GI bleeding (<2 weeks). - Transplant recipients.

Design outcomes

Primary

Measure	Time frame
Diagnostic accuracy of serum NGAL for early AKI detection in decompensated cirrhosis (measured by AUC, sensitivity, specificity at cutoff >150 ng/mL).	—

Secondary

Measure	Time frame
Discriminatory power of RRI (>0.74) for hepatorenal syndrome (HRS) identification (AUC, specificity). 30-day mortality prediction by NGAL (>150 ng/mL) and RRI (>0.74) (adjusted HR via Cox regression). Cost-effectiveness of NGAL-guided ICU triage (reduction in unnecessary transfers by 28%).	—

Countries

Egypt

Contacts

Public ContactRaafat Atya

Lecturer of Internal Medicine

FMAtyaa@medicine.zu.edu.eg00201002719185

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026