Comparative study between intraoperative Nalbuphine infusion vs Fentanyl infusion in Lumbar spine fixation surgeries using TIVA

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

PACTR

Registry ID

PACTR202504661778147

Enrollment

Registered

2025-04-29

Start date

2024-12-10

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Intraoperative Nalbuphine infusion

Intraoperative Fentanyl infusion

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age between 18 and 60 years Both sexes ASA physical status I or II BMI < 30 Patients undergoing elective lumbar spine fixation surgery under TIVA Signed informed consent

Exclusion criteria

Exclusion criteria: Patient refusal Uncontrolled hypertension Significant cardiac or pulmonary diseases Severe kidney disease Pregnancy History of mental illness Hypersensitivity to any study drugs History of previous spine fixation surgery Obesity (BMI = 30)

Design outcomes

Primary

Measure	Time frame
Time to extubation	—

Secondary

Measure	Time frame
Hemodynamic parameters (mean arterial blood pressure, heart rate, and arterial oxygen saturation);Duration of surgery ;Postoperative pain scores (Visual Analog Scale);Time to first rescue analgesia;Total postoperative morphine consumption;Incidence of postoperative complications (e.g., nausea, vomiting, respiratory depression, etc.);Postoperative sedation assessed using the Richmond-Agitation-Sedation Score (RASS)	—

Measure

Time frame

Hemodynamic parameters (mean arterial blood pressure, heart rate, and arterial oxygen saturation);Duration of surgery ;Postoperative pain scores (Visual Analog Scale);Time to first rescue analgesia;Total postoperative morphine consumption;Incidence of postoperative complications (e.g., nausea, vomiting, respiratory depression, etc.);Postoperative sedation assessed using the Richmond-Agitation-Sedation Score (RASS)

—

Countries

Egypt

Contacts

Public ContactAli Genena

Department of Anesthesia Surgical ICU and Pain Management Faculty of Medicine Cairo University

ali.geninah@students.kasralainy.edu.eg+201017881014

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026