Hypertensive disorders of pregnancy
Conditions
Interventions
Twenty four hour magnesium sulphate maintenance injection
Twelve hour magnesium sulphate
Sponsors
Alfa Yusuf
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: INCLUSION CRITERIA. 1. Pregnant women diagnosed with severe pre-eclampsia or eclampsia. 2. Gestational age = 20 weeks. 3. No prior MgSO4 administration before enrolment.
Exclusion criteria
Exclusion criteria: EXCLUSION CRITERIA. Women with pre-eclampsia with severe features or eclampsia with any of the following characteristics will be excluded from the study: • Epilepsy/pre-existing neurological disorders • Hemodynamic instability requiring ICU care • Renal impairment • Acute pulmonary oedema, • Diabetes mellitus and other medical comorbidities. • Hypertensive encephalopathy • Unwilling to give consent for the study • Allergy to magnesium sulphate • Coma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of seizures in pre-eclamptic and eclamptic patients, in each arm of the study | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Mean Serum Magnesium Levels: 2. Safety Outcomes: a. Maternal mortality and ICU admissions. b. MgSO4 toxicity signs: (i) Loss of deep tendon reflexes (DTRs); (ii) Respiratory depression (10 mg/dL) (v) Death c. Adverse effects (nausea, flushing, hypotension, drowsiness, post-partum seizure duration, time to onset of ambulation, and needle abscess or injection site complications) | — |
Countries
Nigeria
Contacts
Public ContactIkemefuna C Nwosu
Consultant
Outcome results
None listed