The possible role of folic acid and vitamin B12 in primary nocturnal enuresis.

Interventional Effects of folic acid and Vitamin B12 in Primary Nocturnal Enuresis in children aged 5-16 years: A Randomized, Double-Blind, Placebo-Controlled trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202503801929185

Enrollment

Registered

2025-03-04

Start date

2023-10-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urological and Genital Diseases

Interventions

folic acid

vitamin B12

placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A monthly average of two or more enuretic episodes. Absent daytime wetting, no dry spells lasting more than 6 months. Not under medical treatment for nocturnal enuresis during the study.

Exclusion criteria

Exclusion criteria: Patients less than 5 years. Patients with chronic diseases, neurological or urological anomalies. Previous recurrent urinary tract infections. Other major medical conditions.

Design outcomes

Primary

Measure	Time frame
to assess whether folic acid and vitamin B12 plus regulating daily habits is superior to regulating daily habits alone in terms of nocturnal enuresis outcomes in children aged 5-16 years identified with primary nocturnal enuresis following screening.	—

Secondary

Measure	Time frame
assessing laboratory and symptomatic outcomes after intervention in children with primary nocturnal enuresis.	—

Countries

Egypt

Contacts

Public Contactasmaa zidan

postgraduate researcher

asmaa_zidan230@yahoo.com201067226398

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026