Efficacy of Dexmedetomidine versus Dexamethasone in Inferior Alveolar Nerve Block: Impact on Postoperative Rebound Pain in Unilateral Mandibulectomy Cancer Surgery.

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

PACTR

Registry ID

PACTR202502890179104

Enrollment

Registered

2025-02-20

Start date

2025-03-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Anaesthesia

Interventions

DEXAMETHASONE Group

DEXMEDETOMIDINE Group

Control Group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.All patients between 18 and 75 years. 2. American Society of Anesthesiologists physical status (ASA) I and II. 3. patients scheduled for elective maxillofacial cancer surgery requiring unilateral mandibular resection.

Exclusion criteria

Exclusion criteria: 1.Patients with surgery involving upper alveolar/ maxillary resection. 2. with body mass index (BMI) below 18 kg/m2 and above 30 kg/m2. 3. ongoing opioid therapy, known allergy to any of the studied drug. 4. pregnant women. 5. Patients unable to give valid consent or with neurological disorders. 6. patients with uncontrolled hemodynamic status (baseline BP above 160/90 mmHg and baseline HR above 100 per minute).

Design outcomes

Primary

Measure	Time frame
Prevalence of postoperative rebound pain of any severity (Numerical pain scale (NRS) >0 on a 0 - 10 scale) in unilateral mandibulectomy cancer surgery.	—

Secondary

Measure	Time frame
1. Postoperative 24-h morphine consumption (mg) 2. The amount of fentanyl used during mandibulectomy resection. 3. HR, SpO2 and mean arterial BP . 4. Time to first rescue analgesia (duration of analgesia) 5. Incidence of postoperative nausea and vomiting. 6. Duration of surgery in minutes. 7. Incidence of intraoperative complications (none, bleeding, technical issues). . Postoperative 24-h morphine consumption (mg)	—

Measure

Time frame

1. Postoperative 24-h morphine consumption (mg) 2. The amount of fentanyl used during mandibulectomy resection. 3. HR, SpO2 and mean arterial BP . 4. Time to first rescue analgesia (duration of analgesia) 5. Incidence of postoperative nausea and vomiting. 6. Duration of surgery in minutes. 7. Incidence of intraoperative complications (none, bleeding, technical issues). . Postoperative 24-h morphine consumption (mg)

—

Countries

Egypt

Contacts

Public Contactahmed mohasseb

Lecturer of Anesthesia

A_medhat88@mans.edu.eg01001272216

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026