Evaluation of the efficacy of post-exposure prophylaxis (PEP) strategy in contacts at high risk of developing Ebola virus disease

Evaluation of the efficacy of post-exposure prophylaxis (PEP) strategy in contacts at high risk of developing Ebola virus disease : EBO-PEP trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202502853321394

Enrollment

240

Registered

2025-02-14

Start date

2025-07-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ebola

Interventions

EBO PEP

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Last high-risk contact within the last 5 days No signs or symptoms of EVD Age = 12 years Signed and dated informed consent to take part in the trial

Exclusion criteria

Exclusion criteria: Previous vaccination with Ervebo or any other EVD vaccine less than 5 years ago (declared by the participant) History of confirmed EVD less than 5 years ago (declared by the participant) Pregnant women (positive pregnancy test) Breastfeeding women Hypersensitivity to one of the investigational medicinal products (IMP) or to their excipients (declared by the participant) Declared severe renal or hepatic insufficiency Participation in another therapeutic or vaccination trial for EVD Any other reason which, at the investigator's discretion, would compromise the participant's safety and cooperation in the trial.

Design outcomes

Primary

Measure	Time frame
To compare the rate of EVD at 21 days in contacts at high risk of EVD receiving a PEP strategy Ervebo + Inmazeb or obeldesivir vs. Ervebo alone	—

Secondary

Measure	Time frame
Comparing safety and tolerance Compare the severity of EVD Compare the proportion of deaths Describe changes in viral load Estimating cost-effectiveness	—

Countries

Democratic Republic of the Congo

Contacts

Public ContactAlice Montoyo

International Project Manager ALIMA

alice.montoyo@coral.alima.ngo+3306601629

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026