An Evaluation the effect of Superhydration versus Dextrose 10% for prevention of Post operative nausea and vomiting after laparoscopic cholecystectomy

Superhydration versus Dextrose 10% for prevention of Post operative nausea and vomiting after laparoscopic cholecystectomy (prospective randomised controlled study)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202502830271505

Enrollment

204

Registered

2025-02-18

Start date

2024-02-25

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Ringer lactate

Superhydration

Dextrose

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1-Age: 21- 60 years 2- Patients with ASA classification I and II

Exclusion criteria

Exclusion criteria: 1. Declining to give written informed consent. 2. Patients with morbid obesity (BMI > 40). 3. ASA classification III-V. 4. Sever hypertension and heart failure. 5. Significant hepatic or renal disorder. 6. Patients with diagnosed diabetes mellitus type 1 or type 2. 7. Patients with history of PONV currently receiving steroids or antiemetics. 8. Pregnant or menstruating patients.

Design outcomes

Primary

Measure	Time frame
To compare the incidence of Post operative nausea and vomiting in the study treatment groups	—

Secondary

Measure	Time frame
Frequency of vomiting episodes; Measurement of PONV severity scores, Severity of PONV was assessed using a 4-point Verbal Descriptive Scale (VDS) which consists of: Score 0= no PONV: no complaint of nausea or vomiting; Score 1= mild PONV: patient complains from nausea but doesn’t need antiemetic treatment. Score 2= moderate PONV: patient complains from nausea and need antiemetic treatment; Score 3= severe PONV: patient complains from nausea with episode of vomiting requiring antiemetic treatment. PONV scores were obtained every half hour;Time from extubation till discharge from PACU;total antiemetic medication consumption Severity of PONV was assessed using a 4-point Verbal Descriptive Scale (VDS) which consists of: Score 0= no PONV: no complaint of nausea or vomiting; Score 1= mild PONV: patient complains from nausea but doesn’t need antiemetic treatment. Score 2= moderate PONV: patient complains from nausea and need antiemetic treatment; Score 3= severe PONV: patient complains from nausea with episode of vomiting requiring antiemetic treatment. PONV scores were obtained every half hour, Rescue antiemetic granisetron 1 mg IV was given when VDS scores were 2 or more. Medications were given only after excluding other causes of PONV such as hypovolemia, hypotension, hypoxia. The total number of doses of antiemetics used were obtained every half hour from the time of entry to the PACU for 4 hours	—

Measure

Time frame

Frequency of vomiting episodes; Measurement of PONV severity scores, Severity of PONV was assessed using a 4-point Verbal Descriptive Scale (VDS) which consists of: Score 0= no PONV: no complaint of nausea or vomiting; Score 1= mild PONV: patient complains from nausea but doesn’t need antiemetic treatment. Score 2= moderate PONV: patient complains from nausea and need antiemetic treatment; Score 3= severe PONV: patient complains from nausea with episode of vomiting requiring antiemetic treatment. PONV scores were obtained every half hour;Time from extubation till discharge from PACU;total antiemetic medication consumption Severity of PONV was assessed using a 4-point Verbal Descriptive Scale (VDS) which consists of: Score 0= no PONV: no complaint of nausea or vomiting; Score 1= mild PONV: patient complains from nausea but doesn’t need antiemetic treatment. Score 2= moderate PONV: patient complains from nausea and need antiemetic treatment; Score 3= severe PONV: patient complains from nausea with episode of vomiting requiring antiemetic treatment. PONV scores were obtained every half hour, Rescue antiemetic granisetron 1 mg IV was given when VDS scores were 2 or more. Medications were given only after excluding other causes of PONV such as hypovolemia, hypotension, hypoxia. The total number of doses of antiemetics used were obtained every half hour from the time of entry to the PACU for 4 hours

—

Countries

Egypt

Contacts

Public ContactWael A. M. Abdelwahab

Assistant professor Ain Shams University Faculty of Medicine

Waelelswefi@med.asu.edu.eg+201224576517

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026