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COMPARISON OF PREOPERATIVE RECTAL MISOPROSTOL AND INTRAOPERATIVE INTRAUTERINE MISOPROSTOL FOR REDUCING BLOOD LOSS DURING CAESAREAN SECTION IN ESUT TEACHING HOSPITAL ENUGU: A RANDOMISED CONTROLLED STUDY

Comparison of preoperative rectal misoprostol and intraoperative intrauterine misoprostol for reducing blood loss during caesarean section in Esut Teaching Hospital Enugu: a randomised controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202502678979460
Enrollment
98
Registered
2025-02-21
Start date
2025-03-16
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy and Childbirth

Interventions

Intraoperative Misoprostol

Sponsors

Dr Chukwuka Chude Eze
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: All consenting women for elective lower segment caesarean delivery under spinal anaesthesia after 37weeks gestational age.

Exclusion criteria

Exclusion criteria: Medical conditions in pregnancy (Hypertension, Diabetes mellitus and known asthmatics) Pregnant women with history of previous uterine surgeries (Caesarean sections, myomectomy etc.) Preoperative anaemia (packed cell volume less than 30% twenty four hours prior to surgery). Pregnant women with history of coagulation disorders Pregnant women with twin gestation Pregnancy co-existing with uterine fibroids Febrile illness before surgery Pregnant women who have contraindication to misoprostol use examples allergy and asthmatics. Cases of Emergency caesarean section and ruptured uterus Cases of APH – Placenta Praevia and Abruptio Placentae.

Design outcomes

Primary

MeasureTime frame
The mean intra-operative blood loss during caesarean delivery and change in haematocrit 48 hours postoperatively.

Secondary

MeasureTime frame
The secondary outcome measures will include the proportion of participants that will need additional uterotonics, and those who received intraoperative blood transfusion, and the need for other surgical intervention for PPH (such as B-lynch procedure, or hysterectomy), incidence of postpartum maternal anaemia and occurrence of adverse effects (nausea, vomiting, allergic reaction, pyrexia, etc.)

Countries

Nigeria

Contacts

Public ContactIfeanyichukwu Ofor

Lecturer 1

ofor.ifeanyi@gmail.com+2348037546411

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026