Ring vaccination trial to evaluate the efficacy and safety of a Sudan ebolavirus vaccine in Uganda - Solidarity against Ebola/Tokomeza Ebola

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202502515126090

Enrollment

150

Registered

2025-02-14

Start date

2025-02-04

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ebola

Interventions

Sudan ebolavirus vaccine randomized to 21 day delayed vaccination

Sudan ebolavirus vaccine randomized to immediate vaccination

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: o Male or female contact of a newly confirmed SUVD index case o At least 6 years of age or older at the time of randomisation. o Capable of giving signed informed consent/assent/have parent(s)/legal guardian capable of giving signed informed consent.

Exclusion criteria

Exclusion criteria: • History of SUVD (self-reported or laboratory confirmed). • History of administration of other experimental treatments in the last 28 days. • History of anaphylaxis from a vaccine or component of a vaccine • Serious bed-confining illness requiring hospitalization at the time of vaccination.

Design outcomes

Primary

Measure	Time frame
Laboratory- Confirmed SUVD •Any probable or suspected case (see definitions below) for which a blood sample has been taken and has been confirmed positive in the laboratory for SUVD, or •Any person deceased due to probable SUVD from whom a post-mortem sample was taken within 48 hours of death and confirmed positive in the laboratory for SUVD.	—

Secondary

Measure	Time frame
Probable SUVD deaths Any person who died suddenly, or with "suspected SUVD" and had a recent epidemiological link to a confirmed case but was not tested and did not have laboratory confirmation of the disease. Suspected SUVD Any person who had sudden onset of a high fever and had had recent contact with a probable or confirmed case of Sudan ebolavirus disease (SUVD) or a dead or sick animal OR any person with sudden onset of high fever and at least three of the following symptoms: headache, vomiting, anorexia/loss of appetite, diarrhea, lethargy, stomach pain, aching, muscles or joints, difficulty swallowing, breathing difficulties, or hiccups; OR any person with unexplained bleeding.	—

Measure

Time frame

Probable SUVD deaths Any person who died suddenly, or with "suspected SUVD" and had a recent epidemiological link to a confirmed case but was not tested and did not have laboratory confirmation of the disease. Suspected SUVD Any person who had sudden onset of a high fever and had had recent contact with a probable or confirmed case of Sudan ebolavirus disease (SUVD) or a dead or sick animal OR any person with sudden onset of high fever and at least three of the following symptoms: headache, vomiting, anorexia/loss of appetite, diarrhea, lethargy, stomach pain, aching, muscles or joints, difficulty swallowing, breathing difficulties, or hiccups; OR any person with unexplained bleeding.

—

Countries

Uganda

Contacts

Public ContactBruce Kirenga

Chief Research Scientist

brucekirenga@yahoo.co.uk256414542803

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026