Mpox Pregnancy and Childbirth
Conditions
Interventions
routine care
Sponsors
Catholic University of Bukavu
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Pregnancy status: all women confirmed to be pregnant at the time of recruitment. Age: women of all ages (assent to be asked for non-legal age to allow for the mother-child pair to benefit from earlier diagnosis, close monitoring, and other advantages the study might offer). Geographical inclusion: residing within the catchment areas of the selected healthcare facilities in South Kivu to ensure that they are likely to continue receiving follow-up care at the participating sites throughout their pregnancy. Symptomatic and asymptomatic participation: Symptomatic: pregnant women presenting with symptoms suggestive of Mpox, such as fever, rash/skin lesion, and/or lymphadenopathy. Asymptomatic: pregnant women attending routine antenatal visits who do not exhibit Mpox-related symptoms but are screened as part of the study's surveillance efforts or who report a confirmed case of Mpox in the household/or among closed contacts Consent: women who provide written informed consent to participate in the study, having understood the purpose, procedures, potential risks, and benefits of the study.
Exclusion criteria
Exclusion criteria: 1. Non-consent: pregnant women who do not consent/or their parent-caregiver to participate in the study. 2. Plans to relocate: women who plan to move out of the geographical study area during the study period, which would interfere with follow-up. 3. Participation in other studies: women currently participating in other studies (such as clinical trials) that might interfere with the results of this study, especially trials involving new experimental treatments for Mpox or other infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of MPVX infection during pregnancy and associated adverse outcomes, such as spontaneous miscarriage, stillbirth, and preterm delivery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunological responses to infection and vaccination, as well as histopathological findings in the placenta of infected mothers. | — |
Countries
Democratic Republic of the Congo
Contacts
Public ContactWyvine Bapolisi
Postdoc researcher
Outcome results
None listed