A Comparative Study between Non-Invasive Continuous Positive Airway Pressure (NICPAP) Ventilation and High Flow Nasal Cannula (HFNC) Oxygenation in Patients with Acute Hypoxemic Respiratory Failure

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

PACTR

Registry ID

PACTR202501708501968

Enrollment

Registered

2025-01-27

Start date

2025-01-25

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Hypoxemic Respiratory Failure

Interventions

NIV CPAP group

HFNC group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Both males and females with age 20–60 years • Diagnosed with AHRF with the following criteria : 1. ARF within one week of a known clinical insult, new, or worsening respiratory symptoms. 2. New infiltrates on chest radiography. 3. Partial pressure of oxygen in arterial blood (PaO2) / fraction of inspired oxygen (FiO2) ratio in arterial blood gases (ABG) 200 4. Arterial carbon dioxide (PaCO2) = 45 mm Hg 5. A decision to initiate NIVCPAP or HFNC oxygenation by attendant physician according to following criteria ( despite conventional oxygen therapy) : • .immediate worsening due to : o Dyspnea . o Hypoxia So2 22 . • Failure of COT after 2 hrs from admission .

Exclusion criteria

Exclusion criteria: ? Urgent need for endotracheal intubation. ? Exacerbation of asthma or chronic pulmonary disease. ? Hemodynamic instability. ? Systolic blood pressure 45 mmHg ? Corona virus disease 2019 (COVID-19) infection. ? Patient refusal or not consenting to participate ? Inability of the patient to protect his airway as in coma or bulbar palsy of any cause ? PaO2/Fio2 ratio < 200

Design outcomes

Primary

Measure	Time frame
•Primary outcomes: treatment failure and need for intubation, the duration of hospital stay, and ICU stay, and mortality rate.Invasive ventilation free days (IVFD): Number of days alive and free of intubation and invasive mechanical intubation within 21 days. It is an indicator of success rate. Time will be counted in hours and rounded to whole days. It will be calculated as 21 minus days of ventilation.	—

Measure

Time frame

•Primary outcomes: treatment failure and need for intubation, the duration of hospital stay, and ICU stay, and mortality rate.Invasive ventilation free days (IVFD): Number of days alive and free of intubation and invasive mechanical intubation within 21 days. It is an indicator of success rate. Time will be counted in hours and rounded to whole days. It will be calculated as 21 minus days of ventilation.

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Secondary

Measure	Time frame
1. Endotracheal intubation rate in both groups: Number of endotracheal intubation and percentages 2.Intensive care unit (ICU) stay days: Time will be counted in hours and rounded to whole days 3.All-causes in hospital mortality rate (time frame 21 days): Number of deaths and percentages	—

Countries

Egypt

Contacts

Public ContactAmr Gabr

icu resident MOH

amr.gabr@med.asu.edu.eg+20201150457177

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026