A randomized clinical trial of oral ketamine versus intravenous acetaminophen for labour analgesia in Ahmadu Bello University Teaching Hospital, Zaria.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

PACTR

Registry ID

PACTR202501504339501

Enrollment

126

Registered

2025-01-23

Start date

2023-08-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy and Childbirth

Interventions

Oral ketamine

IV Acetaminophen

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Parturient in active phase of labour with 4 - 5 cm cervical dilatation 2. Vertex presentation; 3. Single term pregnancy 4. Normal blood pressure 5. No contraindication to vaginal delivery. 6. Foetus in good condition as indicated by normal fetal heart rate.

Exclusion criteria

Exclusion criteria: 1. women with known allergy to ketamine/acetaminophen; 2. previous uterine scar, 3. hypertension, 4. preeclampsia/eclampsia, 5. cardiac disease, 6. liver disease, 7. malpresentation, 8. history of neuropsychiatric disorders, 9. preterm labour, 10. bad obstetric history, 11. parturients whose babies have intrauterine growth restriction 12. patients with any contraindication for vaginal delivery. 13. Patients with cervical dilatation more than 5cm or less than 4cm.

Design outcomes

Primary

Measure	Time frame
oral ketamine had higher efficacy than intravenous Acetaminophen as labor analgesia	—

Secondary

Measure	Time frame
The participants who took oral ketamine were 1. more satisfied with labor analgesia, 2. had shorter duration of labor, 3. good and similar Apar scores, 4. more side effects than those in the control group.	—

Countries

Nigeria

Contacts

Public ContactNana Madugu

Professor

madugu20007@yahoo.com+2348035896570

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026