Two-day versus one-day mifepristone–misoprostol interval prior to initiation of misoprostol during late second trimester medication abortion: Open label superiority randomized trial(Miss TOP MA)

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

PACTR

Registry ID

PACTR202412756696775

Enrollment

224

Registered

2024-12-10

Start date

2024-12-23

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Second trimester abortion

Interventions

2 days Mifepristone to misoprostol interval for second trimester medication abortion

one day mifeprisotone to misoprostol interval

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: -Women undergoing second trimester medication abortion -Gestational age at 20-28 weeks -Volunteering to participate in the study -Women with or without prior uterine scar -Minors and those with congenital anomalies

Exclusion criteria

Exclusion criteria: -Incomplete abortion -Molar pregnancy - Emergency cases admitted and managed at labor ward

Design outcomes

Primary

Measure	Time frame
mean duration (in hours) of induction (start of misoprostol) to expulsion interval	—

Secondary

Measure	Time frame
shorter induction to expulsion interval defined as induction(start of misoprostol) to expulsion interval of =12 hours	—

Countries

Ethiopia

Contacts

Public ContactAmani Nurredin

SPIRHR

amani.nurodin@sphmmc.edu.et+251921402198

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026