Acute kidney injury following major liver resection in both cirrhotic and normal liver: role of goal-directed fluid therapy. A non-randomized controlled trial

Goal-directed fluid therapy during major liver resection in cirrhotic &normal liver.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

PACTR

Registry ID

PACTR202412503100208

Enrollment

Registered

2024-12-03

Start date

2024-05-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Major liver resection in normal liver

liver resection for patients with cirrhotic liver

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Primary or secondary liver tumor •Age of patients with diseased liver between 18-60 years old •Age of patients with normal liver between 18-60years old

Exclusion criteria

Exclusion criteria: • BMI more than 30 • Long standing hypertension •Uncontrolled DM •Other comorbidities that are commonly seen in patients requiring complex surgery, •Known kidney dysfunction, patients needing contrast dye preoperatively, and those on drugs known that are nephrotoxic.

Design outcomes

Primary

Measure	Time frame
incidence of acute kidney injury	—

Secondary

Measure	Time frame
assess the correlation between inferior vena cava index and other hemodynamic indexes (i.e.,Crdiac output, Stroke volume variation ,Systemic vascular resistance, Urine output) at baseline and after parenchymal dissection. Investigate the correlation between IVCD ranging 1.6-2.2 cm and CVP, according to Brennan criteria.	—

Countries

Egypt

Contacts

Public ContactMostafa Abdelkhalek

lecturer of anesthesia and surgical intensive care Faculty of medicine Mansoura university

moustafa.abdelkhale2@mans.edu.eg00201098298593

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026