Improved techniques for sputum collection and the evaluation of non-sputum-based biomarkers for paediatric tuberculosis diagnosis in Ghana.

Utility of improved techniques of specimen collection by sputum induction and the evaluation of non-sputum-based biomarkers for paediatric tuberculosis diagnosis in Ghana.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202412486847941

Enrollment

240

Registered

2024-12-31

Start date

2024-11-25

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tuberculosis

Interventions

Presumptive Pulmonary Tuberculosis cases

Living contacts of Pulmonary Tuberculosis TB cases

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Children younger than 15 years admitted with a suspicion of TB, whose parents or legal guardians give consent and assent (children 8 years and above) for participation, shall be included in the study as cases.

Exclusion criteria

Exclusion criteria: Children who fit the inclusion criteria but are too weak for sputum induction per clinical assessment Children with other respiratory conditions that may affect sputum production. Children for whom informed consent by legal guardians is not provided or do not provide assent (children 8 years and above) shall be excluded from the study. Children below the age of 8 years.

Design outcomes

Primary

Measure	Time frame
1. Quantitative evaluation of the success rates of sputum induction in collecting adequate and quality specimens from paediatric tuberculosis patients in Ghana. 2. Evaluation of how the use of improved sputum collection techniques can improve diagnostic outcomes. 3. Identification of robust T-cells and cytokines biomarkers for the diagnosis of paediatric tuberculosis in Ghana. 4. Assessment of the sensitivity and specificity of T-cells and cytokines biomarkers as diagnostic tools for paediatric tuberculosis in Ghana	—

Measure

Time frame

1. Quantitative evaluation of the success rates of sputum induction in collecting adequate and quality specimens from paediatric tuberculosis patients in Ghana. 2. Evaluation of how the use of improved sputum collection techniques can improve diagnostic outcomes. 3. Identification of robust T-cells and cytokines biomarkers for the diagnosis of paediatric tuberculosis in Ghana. 4. Assessment of the sensitivity and specificity of T-cells and cytokines biomarkers as diagnostic tools for paediatric tuberculosis in Ghana

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Secondary

Measure	Time frame
1. To build the capacity of clinicians and healthcare practitioners in the pediatric tuberculosis management cascade on the safe sputum induction techniques and draft a facility-specific inclusive algorithm for the induction in collaboration with the national TB control program 2. To identify challenges associated with the implementation of the sputum induction algorithm for childhood tuberculosis diagnosis in the Ghanaian clinical setting 3. To identify robust T-cell biomarkers and cytokines able to discriminate pulmonary tuberculosis from other co-infections.	—

Measure

Time frame

1. To build the capacity of clinicians and healthcare practitioners in the pediatric tuberculosis management cascade on the safe sputum induction techniques and draft a facility-specific inclusive algorithm for the induction in collaboration with the national TB control program 2. To identify challenges associated with the implementation of the sputum induction algorithm for childhood tuberculosis diagnosis in the Ghanaian clinical setting 3. To identify robust T-cell biomarkers and cytokines able to discriminate pulmonary tuberculosis from other co-infections.

—

Countries

Ghana

Contacts

Public ContactSandra Kwarteng Owusu

Paediatric Pulmonologist

abenaboamah18@gmail.com+233207343156

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026