Kidney Disease
Conditions
Interventions
Vonoprazane
Sponsors
Cairo university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 140 patients diagnosed with DKD had an albumin/creatinine ratio exceeds 500 mg/day for at least six months before inclusion a glomerular filtration rate (GFR) greater than 30 ml/min All patients were receiving stable treatment with either the maximum tolerated dose of ACE inhibitors or ARBs.
Exclusion criteria
Exclusion criteria: patients with malignancies, liver disease, cardiac failure, acute coronary syndrome, pregnancy, lactation, active infection within the last two months, a history of acid-suppressive drug use within the last three months, a history of upper gastrointestinal system disease or surgery, previous eradication therapy for H. pylori, use of SGLT2 inhibitors and other drugs that can affect proteinuria, a GFR less than 30 ml/min, uncontrolled hypertension requiring new or changing doses of antihypertensive drugs within the last three months, and those unable to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in ACR from baseline and after 3 months of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| The change in eGFR from baseline and after 3 months of treatment. | — |
Countries
Egypt
Contacts
Public ContactAbdelAal Mohammed
Cairo University
Outcome results
None listed