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Nebulized furosemide effect in the treatment of Chronic obstructive pulmonary disease exacerbation: Double blinded randomized study

Nebulized furosemide effect in the treatment of Chronic obstructive pulmonary disease exacerbation: Double blinded randomized study

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
PACTR
Registry ID
PACTR202410667497756
Enrollment
304
Registered
2024-10-04
Start date
2024-10-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory

Interventions

furosemide group
placebo Group

Sponsors

hela Ben Turkia
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Age = 18 years Diagnosed with COPD GOLD 2023 :” Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases and influenced by host factors including abnormal lung development” Presenting with COPD exacerbation Patients who can perform the measurement of FEV1.

Exclusion criteria

Exclusion criteria: - Hemodynamically instability (systolic blood pressure = 90mmHg) - Altered mental status. - Non-invasive mechanical ventilation or intubation at the time of recruitment - More than 6 liters of oxygen at the time of recruitment - Heart failure exacerbation - Hypokalemia - Hypersensitivity to furosemide - Patients that the final diagnosis is not COPD based on specific investigated at one month

Design outcomes

Primary

MeasureTime frame
-Improvement in forced expiratory volume in one second (FEV1)

Secondary

MeasureTime frame
- Change in arterial blood gases. - Change in dyspnea score (VAS) - Emergency department length of stay - Need of admission - Incidence of mortality

Countries

Tunisia

Contacts

Public Contacthanene ghazali

professor

hanene.ghazali@fmt.utm.tn+21658754132

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026