Tuberculosis
Conditions
Interventions
Component 1
Component 2
Component 3
All children will be on intervention arm with the same drugs fro tasting
No cobtrol
Sponsors
Stellenbosch University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: – Aged 3-17-years-old – Consent and assent, as relevant, provided
Exclusion criteria
Exclusion criteria: – Current TB disease (suspected or confirmed) – Current contact with an infectious TB patient – Undergoing dental care or treatment in the past 14 days – The use of mouthwash within 24 hours of the study visit – Smoking in the preceding 48 hours – Known drug allergies or history of hypersensitivity to antibiotics, or intolerance to or unwillingness to eat a culturally appropriate neutral “palate-cleanser” – Children with any current condition that influences taste or smell sensation (such as upper respiratory infection, mucositis, nasal congestion; self-reported sustained taste loss, including due to COVID-19, or use of medication that influences taste perception) – Inability to perform the ranking activity – Children who swallow by mistake or experience difficulty spitting out the solution
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ChilPref SF project has three components (each a swish-and-spit taste panel evaluation) that combine to provide best evidence on what suspending agent(s) and flavours to use in creating extemporaneous suspensions of key medications for RR-TB treatment for child patients | — |
Secondary
| Measure | Time frame |
|---|---|
| This is to contextualise the quantitative data in the words of participants. The researcher will ask the participants to “Tell me, in your own words, what did that taste like, whether they liked it or not and why?” | — |
Countries
South Africa
Contacts
Public ContactTina Sachs
Project manager
Outcome results
None listed