Effects of aminophylline on kidney function in neonates with hypoxic ischemic encephalopathy undergoing therapeutic hypothermia at Kenyatta National Hospital

Effects of aminophylline on kidney function in neonates with hypoxic ischemic encephalopathy undergoing therapeutic hypothermia at Kenyatta National Hospital: Randomized Control Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202409893805769

Enrollment

Registered

2024-09-13

Start date

2024-09-15

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paediatrics

Interventions

Aminophylline

water for injection

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Neonates awaiting to undergo or undergoing therapeutic hypothermia(neonates who fulfilled the cooling criteria in the facility ) • Term neonates and near-term neonates (= 36 weeks gestation by the new Ballard’s score) • Birth weight of > 2kgs • Neonates with Hypoxic Ischemic Encephalopathy (Sarnat and Sarnat score of HIE grade 2 and 3 ) • Consent from parent/guardian

Exclusion criteria

Exclusion criteria: • Preterm infants ( 100mmol/l)

Design outcomes

Primary

Measure	Time frame
effect of aminophylline on kidney functions in neonates with hypoxic ischemic encephalopathy undergoing therapeutic hypothermia	—

Secondary

Measure	Time frame
Compare clinical characteristics of neonates on therapeutic hypothermia after administration of aminophylline versus control (examples include incidence of seizures and incidence of sepsis).	—

Countries

Kenya

Contacts

Public ContactStella Kangethe

Principle Investigator

stekangethe@gmail.com+254721404207

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026