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Evaluating antibody responses longitudinally and correlation to clinical malaria in children who received seasonal vaccination with RTS,S/AS01E with and without seasonal malaria chemoprevention in Mali.

Evaluating antibody responses longitudinally and correlation to clinical malaria in children who received seasonal vaccination with RTS,S/AS01E with and without seasonal malaria chemoprevention in Mali.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202409856142141
Enrollment
855
Registered
2024-09-13
Start date
2024-10-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Genetic Diseases Malaria

Interventions

RTSS vaccine
SMC plus RTSS vaccine

Sponsors

Faculte de pharmacie Universite des Sciences des techniques et des technologies de Bamako
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: i. Participant of RTS,S/AS01E -SMC trial (initial and extension components). ii. Provision of informed consent by a parent or legally recognized guardian for the child. iii. Received all the RTS,S/AS01E or control vaccines as defined in the trial protocols (primary series in April, May, and June 2017, plus booster or control vaccine each year until the child reached 5 years of age).

Exclusion criteria

Exclusion criteria: i. Did not receive the study vaccines as defined in the trial protocols. ii. Dry blood spots not collected during the cross-sectional surveys or missing

Design outcomes

Primary

MeasureTime frame
Natural log mean fluorescent intensity (MFI) of antibody responses to 15 antigenic markers—

Secondary

MeasureTime frame
Mean percentage change in avidity of antibody responses to 15 antigenic markers—

Countries

Mali

Contacts

Public ContactBah Sekou

Dean of the Faculty of Pharmacy Universite des Sciences des Techniques et des Technologies de Bamako

sekoub2000@yahoo.com+22375277527

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026