Efficacy and safety of dexmedetomidine infusion without induction dose on postoperative delirium in geriatric patients undergoing major non cardiac surgeries

Efficacy and safety of dexmedetomidine infusion without induction dose on postoperative delirium in geriatric patients undergoing major non cardiac surgeries: A randomized comparative controlled clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202409743771278

Enrollment

122

Registered

2024-09-19

Start date

2024-10-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Dexmedetomidine

Saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: geriatric patients aged 60 years or older both genders scheduled for elective major non-cardiac surgeries (including orthopedic, urologic, and abdominal surgeries) with an American Society of Anesthesiologists Physical Status I or II

Exclusion criteria

Exclusion criteria: refusal of participation impairment of vision, cognition, or speech neuropsychiatric disease (e.g., dementia, Parkinson’s disease, or cerebrovascular accidents) cardiac dysfunction (i.e., preoperative heart rate <45 beats/minute, any degree of heart block, or sick sinus syndrome) renal failure requiring renal replacement therapy severe liver impairment (Child–Pugh grade C) bleeding disorder emergency surgery intake of antihypertensive medication (such as alpha-methyldopa, clonidine, or other alpha2-adrenergic agonists) cardiac or any emergency surgeries history of allergy to dexmedetomidine

Design outcomes

Primary

Measure	Time frame
The incidence of delirium	—

Secondary

Measure	Time frame
Mean arterial pressure;Heart rate	—

Countries

Egypt

Contacts

Public ContactMohamed Abdelhalim

Department of Anesthesia Surgical Intensive Care and Pain Management Faculty of Medicine Cairo University

mhmdali11082@gmail.com+201066345678

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026