Therapeutic Drug Monitoring for antimicrobial agents for people living with HIV (TAP trial)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202409710100607

Enrollment

Registered

2024-09-02

Start date

2024-09-02

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tuberculosis

Interventions

Therapeutic Drug Monitoring of rifampicin and isoniazid

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Consenting PLWH aged 18 years and above 2. Patients being or who have been initiated on antibiotics which include; amoxicillin (+/- clavulanic acid), azithromycin, ciprofloxacin, rifampicin, isoniazid, ceftriaxone 3. Patients who are willing to and are able to comply with study procedures.

Exclusion criteria

Exclusion criteria: 1. Patients who discontinue antibiotics for any reason following initiation 2. Patients receiving antibiotics only for prophylaxis

Design outcomes

Primary

Measure	Time frame
Pharmacokinetic parameters •Trough concentrations (Ctrough) or minimum concentrations (Cmin) defined as the lowest concentrations achieved prior to subsequent dosing •Maximum concentrations (Cmax) defined as the highest concentration achieved post dosing	—

Secondary

Measure	Time frame
Pharmacodynamic parameters •clinical response to treatment	—

Countries

Uganda

Contacts

Public ContactHope Mackline

Project Manager

hmackline@idi.co.ug256312307000

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026