Accelerated epithelium-off corneal collagen crosslinking with preservation of a central epithelial island in the management of paracentral progressive keratoconus

Accelerated epithelium-off corneal collagen crosslinking with preservation of a central epithelial island in the management of paracentral progressive keratoconus: A Comparative clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202409653243206

Enrollment

160

Registered

2024-09-02

Start date

2023-08-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Diseases

Interventions

Pupil sparing CXL

Epithelium off CXL

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1- Patients age = 18 years 2- Mild to moderate keratoconus (stages I and II on the Amsler–Krumeich scale) 3- Central corneal thickness = 400 mm 4-Documented progression as defined by an increase in K max, K steep, mean keratometry and/or topographic cylinder value = 0.5 D over the previous 6 to 12 months.

Exclusion criteria

Exclusion criteria: 1-Patient with central corneal scarring. 2-Patients with previous ocular surgery 3- Patients with ocular surface pathology or infection 4-Patients with collagen vascular disease concomitant autoimmune diseases and pregnancy

Design outcomes

Primary

Measure	Time frame
To compare early visual acuity improvement, corneal haze, postoperative pain, and discomfort between the two groups	—

Secondary

Measure	Time frame
1- To compare changes in uncorrected visual acuity (UCVA) before and after CXL at the first, 3rd week, 3rd, 6th,and 12th months postoperative between the 2 groups 2- To compare changes in best spectacle corrected visual acuity (BCVA), using the patient’s own glasses before and after CXL at the first, 3rd week, 3rd, 6th,and 12th months postoperative between the 2 groups. 3- To compare manifest refraction, spherical equivalent, cylindrical refraction before and after CXL at the first, 3rd week, 3rd, 6th, 12th, and 24th months postoperative between the two groups. 4- To compare steep K, flat K before and after CXL at the first, 3rd week, 3rd, 6th, 12th, and 24th months postoperative between the two groups. 5- To compare the depth of demarcation line before and after CXL between the two groups.	—

Measure

Time frame

1- To compare changes in uncorrected visual acuity (UCVA) before and after CXL at the first, 3rd week, 3rd, 6th,and 12th months postoperative between the 2 groups 2- To compare changes in best spectacle corrected visual acuity (BCVA), using the patient’s own glasses before and after CXL at the first, 3rd week, 3rd, 6th,and 12th months postoperative between the 2 groups. 3- To compare manifest refraction, spherical equivalent, cylindrical refraction before and after CXL at the first, 3rd week, 3rd, 6th, 12th, and 24th months postoperative between the two groups. 4- To compare steep K, flat K before and after CXL at the first, 3rd week, 3rd, 6th, 12th, and 24th months postoperative between the two groups. 5- To compare the depth of demarcation line before and after CXL between the two groups.

—

Countries

Egypt

Contacts

Public ContactMarwa Ahmed Khairy

lecturer of ophthalmology faculty of medicine Zagazig university

marwakhairy@medicine.zu.edu.eg0201111801956

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026