Effect of combination of chloroquine and primaquine on malaria parasite transmission to mosquitoes compared with chloroquine alone in adult malaria patients in Dilpfan Primary Hospital in Arba Minch, southern Ethiopia

The impact of the combination of primaquine and chloroquine on parasite transmission to mosquitoes and clearance in Plasmodium vivax cases in Ethiopia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202408837266041

Enrollment

Registered

2024-08-02

Start date

2022-04-22

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria

Interventions

Combination of chloroquine and primaquine

Chloroquine alone

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 15 or older Those diagnosed with P. vivax mono-infection by microscopy. Those willing to provide written consent/assent and committed to attending all scheduled visits.

Exclusion criteria

Exclusion criteria: Pregnant and breastfeeding women Individuals with illnesses other than malaria caused by P. vivax mono-infection Those who had taken antimalarial drugs within two weeks before enrollment.

Design outcomes

Primary

Measure	Time frame
The primary outcome variable of this study was the percentage of mosquitoes with oocyst infection, oocyst density, and sporozoite infection rate in the two arms.	—

Secondary

Measure	Time frame
For the secondary outcome, the study aimed to assess the clearance rate of gametocyte and asexual parasites in patients who received treatment with CQ-PQ and those who received CQ alone.	—

Countries

Ethiopia

Contacts

Public ContactAlemu Chemeda

Department Head

alemu.chemeda@amu.edu.et+251910337785

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026