Surgery Orthopaedics Anaesthesia
Conditions
Sponsors
Mansoura University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Patients aged above 50 years and scheduled for elective TKR surgery. • Both genders will be included. • American society of anesthesiologists class I or II
Exclusion criteria
Exclusion criteria: • Operations with severe blood loss. • Patients commenced on cardiac medications interfering with the tested drugs including beta-blockers, calcium channel blockers, monoamine oxidase inhibitors and alpha-receptor blockers. • Patients with congestive heart failure or Cardiac arrhythmia. • Uncontrolled Hypertension or diabetes mellitus • History of renal, hepatic, cardiac, cerebrovascular, thyroid or muscle diseases. • Contraindications for spinal anesthesia like bleeding diathesis, anticoagulant therapy, or local infection at the injection site. • Known allergy to any of the study medications. • Obesity (BMI >30 kg m2 or <20 kg m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypotension in the three study groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| • MAB, SBP, HR changes between the three groups. • Number of rescue boluses commenced in the three groups. • Frequency of hypertensive (SBP > 20% of baseline value), bradycardia ( 100 bpm) episodes. • The incidence of complications including shivering, nausea, vomiting, and headache. • Duration of surgery (min) | — |
Countries
Egypt
Contacts
Public ContactMohamed Eloraby Eloraby
Lecturer of Anesthesia and Surgical ICU. Faculty of Medicine. Mansoura University
Outcome results
None listed