Effect of Dexmedetomidine (Precedex) Administration during Awake Craniotomy on Postoperative Inflammatory Markers and Stress Hormones

Effect of Dexmedetomidine (Precedex) Administration during Awake Craniotomy on Postoperative Inflammatory Markers and Stress Hormones in Patients with Chronic Subdural Hemorrhage: A Randomized controlled Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202408593043200

Enrollment

Registered

2024-08-21

Start date

2024-09-10

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous System Diseases

Interventions

General Anesthesia

Awake Craniotomy with Dexmedetomidine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 18-80 years. Diagnosed with chronic subdural hemorrhage. Scheduled for elective craniotomy. Able to provide informed consent

Exclusion criteria

Exclusion criteria: • Patients with a history of previous brain surgery. • Presence of other significant neurological disorders. • Severe comorbidities (e.g., uncontrolled diabetes, severe cardiac disease). • Allergies or contraindications to dexmedetomidine or anesthetic agents. • Patients requiring emergency surgery.

Design outcomes

Primary

Measure	Time frame
Levels of inflammatory markers (C-reactive protein [CRP], interleukin-6 [IL-6], interleukin-8 [IL-8]) measured preoperatively, immediately postoperatively, and at 24 and 48 hours postoperatively	—

Secondary

Measure	Time frame
Levels of stress hormones (cortisol, noradrenaline) measured preoperatively, immediately postoperatively, and at 24 and 48 hours postoperatively Postoperative pain levels assessed using the Visual Analog Scale (VAS) at 24 and 48 hours postoperatively. Time to discharge from the hospital. Incidence of postoperative complications (e.g., infection, hematoma recurrence). Time to first rescue analgesic request Mean arterial pressure at 0,2,4.8,16and 24 hours postoperatively Heart rate at 0,2,4,8,16 and 24 hours postoperatively	—

Measure

Time frame

Levels of stress hormones (cortisol, noradrenaline) measured preoperatively, immediately postoperatively, and at 24 and 48 hours postoperatively Postoperative pain levels assessed using the Visual Analog Scale (VAS) at 24 and 48 hours postoperatively. Time to discharge from the hospital. Incidence of postoperative complications (e.g., infection, hematoma recurrence). Time to first rescue analgesic request Mean arterial pressure at 0,2,4.8,16and 24 hours postoperatively Heart rate at 0,2,4,8,16 and 24 hours postoperatively

—

Countries

Egypt

Contacts

Public ContactHossam Eldin Abdel Twab

assistant professor of clinical pathology

hosamtwab@mans.edu.eg00201111575606

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026