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Breakthrough in Ascaris lumbricoid Treatment: Single-Dose Albendazole Proves Effective in Ethiopian School children

Breakthrough in Ascaris lumbricoid Treatment: Single-Dose Albendazole Proves Effective in Ethiopian School children

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
PACTR
Registry ID
PACTR202407793260730
Enrollment
150
Registered
2024-07-23
Start date
2023-06-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Digestive System

Interventions

Albendazole drug

Sponsors

Mesgenaw Tefesa
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All school children whose ages ranged from 7-14 years old attending and who had microscopically confirmed A. lumbricoid mono-infection without history of anti-helminthic drugs in take within the last 6 months before study period and able to to provide required stool samples at the baseline, after 2- 3 weeks and 3 months of baseline albendazole treatment were included in the study

Exclusion criteria

Exclusion criteria: School-age children unable to bring parents/legal guardian to the school, who have a history of known major systemic or chronic illnesses, malnutrition, and GIT diseases, who take anti-in?ammatory drugs/ antibiotics during the study period based on vital signs and prior clinical history, who have been vomiting within 4 hours after drug administration, experienced diarrhea , severe allergic reaction to albendazole, Infected with other than intestinal parasite than A.lumbricoide were excluded from the study

Design outcomes

Primary

MeasureTime frame
Cure rate or CR .CR means the proportion of individual hosts positive for parasites who become parasitologically negative after treatment or at 14-21 days

Secondary

MeasureTime frame
Egg reduction rate or ERR. Arithmetic mean of Feacal Egg Reduction Rate OR ERR. ERR is the arithmetic mean egg count at baseline of the treatment group minus mean egg count at the end of treatment period divided by the mean egg count at the baseline and express it in percent.;Magnitude of reinfection . The proportion childern who was cured at 14-21 days of treatment divided by the number of re-infected after the three months of albednazole treatments

Countries

Ethiopia

Contacts

Public ContactTegegne;Ababaw Eshetu;Setegn

Lectuer at University of Gondar;Lectuer at university of Gondar

tegegneeshetu5@gmail.com;abebawsetegn@gmail.com+251918007997;+251945807430

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026