Anaesthesia
Conditions
Sponsors
Faculty of medicine at Ain Shams University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients in the age group more than 65 years of either sex. ASA (American society of anesthesiologists) physical status I-III. Patient undergoing any kind of surgery requiring general anesthesia except cardiac surgery.
Exclusion criteria
Exclusion criteria: Adult patients in the age group less than 65 years of either sex. Patients who have history of allergy to Propofol or thiopental. Diagnosed Alzheimer disease, dementia, and previous cerebrovascular accident. History of cardiac disease (Ischemic heart disease, heart failure, and/or valvular heart disease with established myocardial function impairment). ASA IV. Long term use of drugs affecting central nervous system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypotension till 30 minutes post induction of general anesthesia.Measurement of systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure MAP at baseline, and T1-T6 till up to 3 min post intubation will be done using M-entropy module (S5 Datex Ohmeda, Instrumentarium Corp., Helsinki, Finland). T0=Baseline (before fentanyl). • T1 = Induction. • T2 = 1 min post induction. • T3 = 3 min post induction. • T4 = immediately following laryngoscopy. • T5 = 1 min post intubation. • T6 = 3 min post intubation (volatile anesthetic started at this point). | — |
Secondary
| Measure | Time frame |
|---|---|
| The initial consumption of propofol and thiopental until defined entropy hypnosis level is obtained , titrated to response entropy (RE) of 40.;High-sensitive Troponin I levels to assess the occurrence of myocardial ischemia among the patients secondary to hypotension .;The change in heart Rate | — |
Countries
Egypt
Contacts
Public ContactYasmin El Emary
Assistant lecturer at department of anesthesiology at faculty of medicine Ain shams university
Outcome results
None listed