Effect of Positive End Expiratory Pressure on pulmonary Shunt During Laparoscopic cholecystectomy

Effect of Different Levels of Positive End Expiratory Pressure on pulmonary Shunt During Laparoscopic cholecystectomy

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

PACTR

Registry ID

PACTR202405920464720

Enrollment

Registered

2024-05-31

Start date

2023-12-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Group A

Group B

Group C

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with the American Society of Anesthesiologists (ASA) physical status I/II of both sexes undergoing elective laparoscopic cholecystectomy 2. Age between 18 and 65 years. 3. Body mass index (BMI) of 18-35 kg/m2.

Exclusion criteria

Exclusion criteria: 1. Patient refusal to participate in the study. 2. Body mass index more than 40 kg/m2. 3. Preoperative anemia (Hemoglobin <10gm/dl) 4. Severe hemodynamic unstability (mean blood pressure <60mmHg ) 5. Patients with high peak inspiratory pressure more than 30 CmH2O before PEEP setting 6. Cardiovascular diseases and previous history of pulmonary embolism. 7. Severe Respiratory diseases (obstructive and restrictive lung diseases) 8. Smokers. 9. Pregnancy.

Design outcomes

Primary

Measure	Time frame
evaluate the effect of different levels of PEEP on pulmonary shunt during laparoscopic cholecystectomy using alveolo-arterial gradient	—

Secondary

Measure	Time frame
to evaluate the effect of different levels of positive end expiratory pressure on • Lung mechanics (peak inspiratory pressure, plateau pressure and dynamic compliance). • Hemodynamics (mean arterial blood pressure and heart rate). • Peripheral oxygen saturation.	—

Countries

Egypt

Contacts

Public Contacteman Awaad

anasthesia lecturer

emankamal85@hotmail.com0012345667

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026