Pregnancy and Childbirth
Conditions
Interventions
Normal Saline
Sponsors
Busitema University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: We will include patients with obstructed labour carrying singleton, term pregnancies (=37 weeks of gestation) in cephalic presentation.
Exclusion criteria
Exclusion criteria: We will exclude patients with other obstetric emergencies such as antepartum haemorrhage, preeclampsia and eclampsia (defined as elevated blood pressure of at least 140/90 mm Hg, urine protein of at least 2+, any of the danger signs and fits), premature rupture of membranes and intrauterine fetal death. Patients with comorbidities such as diabetes mellitus, sickle cell disease, renal disease, liver disease and heart disease. We will also exclude those patients with hypokalaemia (148 mmol/L) and alkalosis (bicarbonate >22 mmol/L) because they are more likely to develop adverse drug reactions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure will be the mean change in maternal pH from baseline in each group. In umbilical blood it will be the mean pH in each arm of the study | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes will include mean lactate in maternal and umbilical blood, early neonatal death, safety (side effects) of sodium bicarbonate, primary postpartum hemorrhage, sepsis and death. Furthermore, the plasma concentrations of bicarbonate levels will be measured as well to accurately estimate the required dose. | — |
Countries
Uganda
Contacts
Public ContactRitah Nantale
Research Manager
Outcome results
None listed