Efficacy of Combined Anodal tDCS over M1 and F3 Regions in Diabetic Neuropathic Pain: Double-blind Randomized Controlled Study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202405874828622

Enrollment

Registered

2024-05-14

Start date

2024-05-30

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous System Diseases

Interventions

Group 2 Sham

Group 1

Group 1 tDCS

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Type 2 diabetic patients according to the 1999 World Health Organization (WHO) diagnostic criteria Type-2 diabetes and neuropathic pain, at least 5 years of diabetes history • Aged 45 to 65 years, • Ability and willingness to participate in intervention sessions.

Exclusion criteria

Exclusion criteria: • Use of strong painkillers • Medical conditions causing NP as herniated disc or stroke • History of head or neck surgery. • Use of a cardiac pacemaker or defibrillator • Subjects with diabetic foot ulcers and amputation • Absence in more than two sessions or more than four days between sessions

Design outcomes

Primary

Measure	Time frame
To investigate the diabetic neuropathic pain before and after treatment with combined anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions measured by McGill Pain questionnaire.;To investigate the diabetic neuropathic pain before and after treatment with combined anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions measured by McGill Pain questionnaire.;To investigate the diabetic neuropathic pain before and after treatment with combined anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions measured by McGill Pain questionnaire.	—

Measure

Time frame

To investigate the diabetic neuropathic pain before and after treatment with combined anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions measured by McGill Pain questionnaire.;To investigate the diabetic neuropathic pain before and after treatment with combined anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions measured by McGill Pain questionnaire.;To investigate the diabetic neuropathic pain before and after treatment with combined anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions measured by McGill Pain questionnaire.

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Secondary

Measure	Time frame
1- To investigate the possible effect of anodal transcranial direct current stimulation (tDCS) on the systemic immune-inflammatory index. 2- To investigate the effect of combined anodal transcranial direct current stimulation on the hospital anxiety and depression scale. ;1- To investigate the possible effect of anodal transcranial direct current stimulation (tDCS) on the systemic immune-inflammatory index. 2- To investigate the effect of combined anodal transcranial direct current stimulation on the hospital anxiety and depression scale.	—

Measure

Time frame

1- To investigate the possible effect of anodal transcranial direct current stimulation (tDCS) on the systemic immune-inflammatory index. 2- To investigate the effect of combined anodal transcranial direct current stimulation on the hospital anxiety and depression scale. ;1- To investigate the possible effect of anodal transcranial direct current stimulation (tDCS) on the systemic immune-inflammatory index. 2- To investigate the effect of combined anodal transcranial direct current stimulation on the hospital anxiety and depression scale.

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Countries

Egypt

Contacts

Public ContactMary;Mary Atef Nassif; Atef Nassif

Lecturer of Physical Medicine Rheumatology and Rehabilitation;Lecturer of Rheumatology Rehabilitation and Physical Medicine

yan_rheum@med.asu.edu.eg;yan_rheum@med.asu.edu.eg01006135348;01006135348

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026