Studying immune system variation and variation in vaccine response using yellow fever vaccine.
Conditions
Interventions
Yellow fever vaccine
Sponsors
Kilimanjaro Christian Medical Centre KCMC
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. People who are permanent residents of the selected areas and expected to stay during the whole duration of the study 2. Aged 18-35 years 3. Accepted written consent
Exclusion criteria
Exclusion criteria: 1. Clinically significant history of diseases like HIV, TB, Cancer, Cardiovascular diseases, gastrointestinal disease, liver disease, renal disease, an endocrine disorder, or neurological illness. 2. History of recurrent infections and being admitted 2 or more times a year at hospital and receiving antibiotics as it will be shown in discharge summary. 3. History of long-term use of corticosteroids for any reasons, i.e. concurrent oral or systemic steroids medication or the concurrent use of other immunosuppressive agents within 2 to 3 months before enrolment. 4. Hospital admission in the past 3 months 5. Any history of being the recipient of vaccines that will be used during the study 6. Positive HIV serology 7. Haemoglobin levels less than 8.5 g/dl 8. A positive pregnancy test at the start or during the study 9. History of nose bleeding 10. Female currently lactating 11. Transfusion of blood products within three months before the study 12. Received immunoglobulins within three months before the study 13. Low blood pressure =90/60 mm Hg 14. High blood glucose >7.1 mmol l-1 fastings or >11.1 mmol l-1 random RBG
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune Response antibody titers and cellular response memory T and B cells | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety and side effects. | — |
Countries
Tanzania
Contacts
Public ContactMarloes van Dorst
LUMC
Outcome results
None listed