Nervous System Diseases
Conditions
Interventions
Real repetitive Transcranial Magnetic Stimulation of DLPFC
Real repetitive Transcranial Magnetic Stimulation over SMA
Sham repetitive Transcranial Magnetic Stimulation of DLPFC or of SMA
Sponsors
Science Technology and Innovation Funding Authority
Neurology department Ain Shams University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: -Definite MS patients according to 2017 revisions of the McDonald criteria. -Progressive types of MS: Patient must fulfill diagnostic criteria of either: Secondary progressive MS (SPMS) or Primary progressive MS (PPMS) -Free of clinical relapses for at least 3 months prior to inclusion. -Free of steroid treatment for at least 6 weeks prior to inclusion. -No change in their medications, whether disease modifying treatment or symptomatic therapy for at least 3 months if applicable. -EDSS score = 6 points and stable over the past 3 months. -A score of <34 on Symbol Digit Modalities Test, a score of = 12 on the Beck Depression Inventory (Beck et al., 1961), a score of = 38 on the Modified Fatigue Impact Scale. -Level of education: at least can read and write. -Written informed consent from the participants
Exclusion criteria
Exclusion criteria: -Conditions that could affect the participants’ level of cognition, fatigue, or depression, including; pregnancy, history of substance use disorder, history of significant neurological disorder other than MS, psychiatric, endocrinological, hepatic, renal, collagen, or other systemic comorbidities that could affect these symptoms. -Contraindication to TMS: history of seizures, skull bone defects, metal fragments in the head, implanted metallic devices such as cardiac pacemakers, cochlear implants, medical pumps…, etc. -Illiterate patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the efficacy of high frequency rTMS on cognitive impairment using Symbol Digit Modalities Test, fatigue using Arabic version of Modified Fatigue Impact Scale, and depression using Arabic version of Beck Depression inventory in a sample of Egyptian progressive MS patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the effects of high frequency rTMS on the patients’ MS-related sphincteric dysfunction using the Arabic International Consultation on Incontinence Questionnaire-Short Form Scale, and on the patients’ walking performance using Timed 25-Foot walk test and Functional Ambulation Category. | — |
Countries
Egypt
Contacts
Public ContactAzza Abdelnasser
Professor of Neurology Ain Shams University
Outcome results
None listed