Nervous System Diseases
Conditions
Interventions
Administering Pre emptive Antibiotic tretament
Sponsors
None
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All adults (age 18 and above) presenting with compound skull vault fractures who have: 1. Received primary wound care within 12 hours of injury. 2. Receive definitive surgery within 72 hours of injury. 3. Received a single dose of 2g Cefazolin intravenously within 12 hours of injury and have any one of the following risk factors for septic complications: - air sinus involvement - or clinical or radiological evidence of wound contamination
Exclusion criteria
Exclusion criteria: Children under the age of 18. Gunshot injuries. Septic complication at time of presentation. Compound skull fractures with no high-risk features. Patients suffering from base of skull fractures only. Closed skull fractures. Known antibiotic allergy. Patients known with severe comorbidities such as end stage renal disease, heart failure, liver failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A Reduction in the incidence of septic complications to 3 percent. | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurological outcomes at 6 weeks post treatment follow will be assessed | — |
Countries
South Africa
Contacts
Public ContactRuan Grobler
PhD Student Stellenbosch University
Outcome results
None listed